What is alpha isomethyl ionone – and is it safe?

Alpha isomethyl ionone – sometimes called isomethylionone – is a fragrance compound sometimes used in cosmetics and household cleaning products – for instance in soaps, hair care products, perfumes, fabric conditioners and detergents. Dove, Olay and Nivea use it in a number of products, for instance, and it is in such fragrances as Paco Rabanne’s 1 Million for men and Lady Million Eau de Parfum for women. 

Given the similarity of its name to methylisothiazolinone, it’s not surprising that we’ve been asked a few times whether it’s safe for isothiazolinone allergic people – nor that it comes up regularly as a question on the Allergy to Isothiazolinone, Methylisothiazolinone and Benzisothiazolinone Facebook Page.  

Fabric conditioner with four isothiazolinones – and alpha isomethyl ionone too

Alpha isomethyl ionone is a fragrance, isothiazolinones are preservatives, the two chemical families are not related, and from an MI-allergy perspective, it is definitely not an isothiazolinone preservative and accordingly should not cause cross reactions. 

That said, it is a potential skin sensitiser and allergen in its own right, and is one of the 26 fragrance allergens which EU cosmetics laws have specified should be declared on lists of ingredients (in fact, alphabetically, it is the first). It isn’t found in either Fragrance Mix I or Fragrance Mix 2 in the contact dermatitis testing panels, so will be tested in isolation if you undergo contact dermatitis patch testing. It is possible to be allergic to both it and to MI. 

Cosmetics Info say that it is a synthetic – that is, artificially produced – fragrance compound, therefore any product or brand claiming to be free from synthetic or artificial fragrances should in theory be safe for you, if you do have an allergy to it.

In all probability, brands which pride themselves as natural or are certified by a natural or organic body will probably be alpha isomethyl ionone-free – as well as isothiazolinone free – but you must always double check, for either case.

So-called fragrance free cosmetics should also be free of alpha isomethyl ionone – though will not necessarily be free from MI / MCI, and will be free of other fragrances which you may not in fact react to.

As always in the above cases – make sure to check the label, and double check with the manufacturer if you can or if you are uncertain. 

Other names for alpha isomethyl ionone, which may be seen on non-cosmetic products, include gammanolene and irisantheme. Its CAS number is 127-51-5. You may come across the name hyphenated or with alternate spacing / word separation – eg alpha-iso-methylionone.


  1. Amanda Mullen

    Eden perfumes in the UK claims to make all natural dupes of well-known brands. But every one of their fragrances contains alpha-isomethyl ionone. Quite annoying.

    1. MI Free (Post author)

      Are you definitely sensitive to alpha isomethyl ionone? Do Eden not do bespoke options without certain ingredients such as this one?

  2. Amanda Mullen

    It’s not so much a case of being sensitive to it as it’s classification as a potential human toxin. But no, Eden don’t offer any perfumes without that ingredients. Typical greenwashing.

    1. MI Free (Post author)

      Not sure who might have classified it as a ‘human toxin’ (if the EWG, then I’m afraid I’m sometimes sceptical of their work), but even if so, it’s the question of dose that determines toxicity, and as a fragrance chemical it would be used in small amounts, determined safe by the SCCS, I presume, in the EU. As it’s artificial, though, the issue of greenwashing is indeed valid as it’s non-natural. I did tweet Eden about your comment, but they’ve not replied on Twitter either.

  3. Roseann

    Is there a list of items/cosmetics we with MI can use? Its usually mono gumbo. Just spit it out. Please

    1. MI Free (Post author)

      Excuse me? Not sure what you mean by ‘mono gumbo’, but there are lists in the drop-down resources in the menu across the top of the site. Thanks.


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